Millipore- 1.58793 Page 1 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006 Version 6.9 Revision Date 02.07.2024 Print Date 07.07.2024 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers Product name : Sodium hydroxide solution 50% for analysis EMSURE® Product Number : 1.58793 Catalogue No. : 158793 Brand : Millipore REACH No. : CAS-No. : 1310-73-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Reagent for analysis, Chemical production Uses advised against : This product is not intended for consumer use. 1.3 Details of the supplier of the safety data sheet Company : Merck KGaA Frankfurter Str. 250 D-64271 DARMSTADT Telephone : +49 (0)6151 72-0 Fax : +49 6151 727780 E-mail address : TechnicalService@merckgroup.com 1.4 Emergency telephone Emergency Phone # : +(44)-870-8200418 (CHEMTREC (GB)) +(353)-19014670 (CHEMTREC Ireland) 001-803-017-9114 (CHEMTREC India) SECTION 2: Hazards identification 2.1 Classification of the substance or mixture Corrosive to Metals, (Category 1) H290: May be corrosive to metals. Skin corrosion, (Sub-category 1A) H314: Causes severe skin burns and eye damage. Serious eye damage, (Category H318: Causes serious eye damage. Millipore- 1.58793 Page 2 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada 1) 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal Word Danger Hazard Statements H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. Precautionary Statements P234 Keep only in original packaging. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P363 Wash contaminated clothing before reuse. Supplemental Hazard Statements none Reduced Labeling (<= 125 ml) Pictogram Signal Word Danger Hazard Statements H314 Causes severe skin burns and eye damage. Precautionary Statements P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P363 Wash contaminated clothing before reuse. Supplemental Hazard Statements none Millipore- 1.58793 Page 3 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Ecological information: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Toxicological information: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. SECTION 3: Composition/information on ingredients 3.2 Mixtures Component Classification Concentration sodium hydroxide CAS-No. EC-No. Index-No. Registration number 1310-73-2 215-185-5 011-002-00-6 01-2119457892-27- XXXX Met. Corr. 1; Skin Corr. 1A; Eye Dam. 1; H290, H314, H318 Concentration limits: >= 5 %: Skin Corr. 1A, H314; 2 - < 5 %: Skin Corr. 1B, H314; 0,5 - < 2 %: Skin Irrit. 2, H315; 0,5 - < 2 %: Eye Irrit. 2, H319; >= 0,4 %: Met. Corr. 1, H290; >= 50 - < 70 % For the full text of the H-Statements mentioned in this Section, see Section 16. SECTION 4: First aid measures 4.1 Description of first-aid measures General advice First aiders need to protect themselves. If inhaled After inhalation: fresh air. Call in physician. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately. In case of eye contact After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses. Millipore- 1.58793 Page 4 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada If swallowed After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Sodium oxides Not combustible. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Suppress (knock down) gases/vapors/mists with a water spray jet.Prevent fire extinguishing water from contaminating surface water or the ground water system. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid substance contact. Do not breathe vapors, aerosols. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.Advice for emergency responders: For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® OH⁻, Merck Art. No. 101596). Dispose of properly. Clean up affected area. 6.4 Reference to other sections For disposal see section 13. Millipore- 1.58793 Page 5 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada SECTION 7: Handling and storage 7.1 Precautions for safe handling Advice on safe handling Observe label precautions. Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions No aluminium, tin, or zinc containers. Tightly closed.No metal containers. Recommended storage temperature see product label. Storage class Storage class (TRGS 510): 8B: Non-combustible, corrosive hazardous materials 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection 8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Tightly fitting safety goggles Skin protection This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please Millipore- 1.58793 Page 6 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:KCL 741 Dermatril® L Body Protection protective clothing Respiratory protection Recommended Filter type: Filter type P2 The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains. SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Physical state liquid b) Color colorless c) Odor odorless d) Melting point/freezing point Melting point: 12 °C e) Initial boiling point and boiling range 135 °C at 1.013 hPa f) Flammability (solid, gas) No data available g) Upper/lower flammability or explosive limits No data available h) Flash point Not applicable i) Autoignition temperature No data available j) Decomposition temperature No data available k) pH ca.14 at 89 g/l at 20 °C l) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: 79 mPa.s at 20 °C m) Water solubility at 20 °C completely miscible Millipore- 1.58793 Page 7 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada n) Partition coefficient: n-octanol/water No data available o) Vapor pressure 2 hPa at 20 °C p) Density 1,52 g/cm3 at 20 °C Relative density No data available q) Relative vapor density No data available r) Particle characteristics No data available s) Explosive properties Not classified as explosive. t) Oxidizing properties none 9.2 Other safety information No data available SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability No data available 10.3 Possibility of hazardous reactions Risk of ignition or formation of inflammable gases or vapours with: Metals Light metals Possible formation of: Hydrogen Violent reactions possible with: ammonium compounds Cyanides organic nitro compounds organic combustible substances phenols powdered alkaline earth metals Acids Nitriles Magnesium 10.4 Conditions to avoid no information available 10.5 Incompatible materials Aluminum, various plastics, Brass, Metals, metal alloys, Zinc, Tin, Light metals, glass, quartzes/silicate ceramics, animal/vegetable tissues Millipore- 1.58793 Page 8 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada 10.6 Hazardous decomposition products In the event of fire: see section 5 SECTION 11: Toxicological information 11.1 Information on toxicological effects Mixture Acute toxicity Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach. Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract Dermal: No data available Skin corrosion/irritation Remarks: Necrosis Mixture causes severe burns. Serious eye damage/eye irritation Remarks: Mixture causes serious eye damage. Risk of blindness! Necrosis Respiratory or skin sensitization No data available Germ cell mutagenicity No data available Carcinogenicity No data available Reproductive toxicity No data available Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information Endocrine disrupting properties Product: Assessment The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Millipore- 1.58793 Page 9 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada Irritation and corrosion, Risk of blindness!, Cough, Shortness of breath Irritation and corrosion Cough Shortness of breath collapse death Risk of blindness! Other dangerous properties can not be excluded. Handle in accordance with good industrial hygiene and safety practice. Components sodium hydroxide Acute toxicity Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach. Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible damages:, damage of respiratory tract Dermal: No data available Skin corrosion/irritation Skin - Rabbit Result: Causes burns. Remarks: (Regulation (EC) No 1272/2008, Annex VI) Serious eye damage/eye irritation Eyes - Rabbit Result: Causes serious eye damage. (OECD Test Guideline 405) Remarks: (Regulation (EC) No 1272/2008, Annex VI) Remarks: Causes serious eye damage. Respiratory or skin sensitization Patch test: - In vitro study Result: negative Remarks: (ECHA) Germ cell mutagenicity No data available Carcinogenicity No data available Reproductive toxicity No data available Specific target organ toxicity - single exposure Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach. Acute inhalation toxicity - burns of mucous membranes, Cough, Shortness of breath, Possible damages:, damage of respiratory tract Millipore- 1.58793 Page 10 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available SECTION 12: Ecological information 12.1 Toxicity Mixture No data available 12.2 Persistence and degradability The methods for determining the biological degradability are not applicable to inorganic substances. No data available 12.3 Bioaccumulative potential No data available 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. 12.7 Other adverse effects Harmful effect due to pH shift. Death of fish possible. Does not cause biological oxygen deficit. Neutralisation possible in waste water treatment plants. Discharge into the environment must be avoided. No data available Components sodium hydroxide Toxicity to fish LC50 - Gambusia affinis (Mosquito fish) - 125 mg/l - 96 h Remarks: (ECOTOX Database) Toxicity to daphnia and other aquatic invertebrates EC50 - Ceriodaphnia (water flea) - 40,4 mg/l - 48 h Remarks: (ECHA) Millipore- 1.58793 Page 11 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada Toxicity to bacteria EC50 - Photobacterium phosphoreum - 22 mg/l - 15 min Remarks: (External MSDS) SECTION 13: Disposal considerations 13.1 Waste treatment methods Product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions. SECTION 14: Transport information 14.1 UN number ADR/RID: 1824 IMDG: 1824 IATA: 1824 14.2 UN proper shipping name ADR/RID: SODIUM HYDROXIDE SOLUTION IMDG: SODIUM HYDROXIDE SOLUTION IATA: Sodium hydroxide solution 14.3 Transport hazard class(es) ADR/RID: 8 IMDG: 8 IATA: 8 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user Tunnel restriction code : (E) Further information : No data available SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.2 Chemical Safety Assessment A Chemical Safety Assessment has been carried out for this substance. Millipore- 1.58793 Page 12 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada SECTION 16: Other information Full text of H-Statements H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. Full text of other abbreviations ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways; ADR - Agreement concerning the International Carriage of Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM - American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response; ELx - Loading rate associated with x% response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration associated with x% growth rate response; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RID - Regulations concerning the International Carriage of Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative Classification of the mixture Classification procedure: Met. Corr.1 H290 Based on product data or assessment Skin Corr.1A H314 Calculation method Eye Dam.1 H318 Calculation method Millipore- 1.58793 Page 13 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada Further information The information is believed to be correct but is not exhaustive and will be used solely as a guideline, which is based on current knowledge of the chemical substance or mixture and is applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. 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